Abstract Background Germline TP53 mutations are associated with Li-Fraumeni syndrome, a severe and rare hereditary cancer syndrome.Despite the rarity of germline TP53 mutations, the clinical implication for mutation carriers and their families is significant.The risk management of TP53 germline mutation carriers is more stringent than BRCA carriers
Microbial drinking water quality in premise plumbing systems (PPSs) strongly affects public health.Bacterial community structure is the essential aspect of microbial water quality.Studies have elucidated the microbial community structure in cold tap water, while the microbial community structures in hot tap and shower water are poorly understood.We
In crowded waters, the incidence of collision accidents of multiple vessels has increased significantly, most of which can be ascribed to human factors, particularly, human decision-making failures and inobservance with International Regulations for Preventing Collisions at Sea (COLREGS).On this basis, an automatic collision avoidance strategy for
Skin chronically exposed to sun results in phenotypic changes referred as photoaging.This aspect of aging has been studied extensively through genomic and proteomic tools.Metabolites, the end product are generated as a result of biochemical reactions are often studied as a culmination of complex interplay of gene and protein expression.In this belt